Unequal Crossing Over During Prophase I Can Result in One

question 17

Multiple Choice

Unequal crossing over during prophase I can result in one sister chromosome with a deletion and another with a duplication. A mutated form of haemoglobin, so-called haemoglobin Lepore, exists in the human population. Haemoglobin Lepore has a deleted series of amino acids. If this mutated form was caused by unequal crossing over, what would be an expected consequence?

• A) There should also be persons whose haemoglobin contains two copies of the series of amino acids that is deleted in haemoglobin Lepore.
• B) Each of the genes in the haemoglobin gene family must show the same deletion.
• C) The deleted gene must have undergone exon shuffling.
• D) The deleted region must be located in a different area of the individual's genome.

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