Rank the Following One-Base Point Mutations with Respect to Their

question 21

Multiple Choice

Rank the following one-base point mutations with respect to their likelihood of affecting the structure of the corresponding polypeptide (from most likely to least likely) .
1) insertion mutation deep within an intron
2) substitution mutation at the third position of a codon in an exon
3) substitution mutation at the second position of a codon in an exon
4) deletion mutation within the first exon of the gene

• A) 1, 2, 3, 4
• B) 4, 3, 2, 1
• C) 2, 1, 4, 3
• D) 3, 1, 4, 2

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Definitions:

RNA Polymerases

Enzymes that are responsible for transcribing RNA from a DNA template, playing a key role in the process of gene expression.

Transcription

The process by which the genetic information in DNA is copied into messenger RNA (mRNA) for protein synthesis.

tRNA Triplet

A sequence of three nucleotides in transfer RNA that is complementary to a specific messenger RNA codon during protein synthesis.

mRNA

Messenger RNA, a form of RNA that transfers genetic instructions from DNA to the ribosome for protein synthesis.