Exposure of Zebrafish Nuclei to Cytosol Isolated from Eggs at Metaphase

question 9

Multiple Choice

Exposure of zebrafish nuclei to cytosol isolated from eggs at metaphase of mitosis resulted in phosphorylation of NEP55 and L68 proteins by cyclin-dependent kinase 2. NEP55 is a protein of the inner nuclear membrane, and L68 is a protein of the nuclear lamina. What is the most likely role of phosphorylation of these proteins in the process of mitosis?

• A) They enable the attachment of the spindle microtubules to kinetochore regions of the centromere.
• B) They are involved in chromosome condensation.
• C) They are involved in the disassembly of the nuclear envelope.
• D) They assist in the migration of centrosomes to opposite sides of the nucleus.

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