The Enzyme Phosphofructokinase (PFK) Catalyses a Key Step in Glycolysis

question 42

Multiple Choice

The enzyme phosphofructokinase (PFK) catalyses a key step in glycolysis. About 10% of Springer spaniels suffer from canine PFK deficiency. Given its critical role in glycolysis, which of the following conditions would be a likely consequence for dogs afflicted with this disorder?

• A) They would die as embryos.
• B) They would have elevated blood-glucose levels, which may result in a high incidence of diabetes.
• C) They would be lethargic and readily tire from exercise.
• D) They would carry out elevated levels of oxidative phosphorylation.

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