"The Native Structure of H[a]emoglobin (Hb) Comprises of Two α

question 36

Multiple Choice

"The native structure of h[a]emoglobin (Hb) comprises of two α and two β subunits, each of which carries a h[a]em group. There appear to be no previous studies that report the in-vitro folding and assembly of Hb from highly unfolded α and β globin in a 'one-pot' reaction. One difficulty that has to be overcome for studies of this kind is the tendency of Hb to aggregate during refolding. This work demonstrates that denaturation of Hb in 40% acetonitrile at pH 10.0 is reversible." (J Am Soc Mass Spectrum 2007, 18, 8-16)
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How many haeme groups are present in three haemoglobin protein molecules?

• A) 3
• B) 4
• C) 9
• D) 12

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Definitions:

Novation

The act of replacing an obligation to perform with a new obligation, or substituting a new party into an existing contract.

Successive Assignments

The process of transferring rights or duties from one party to another over a series of transactions.

Obligor

The party in a contractual agreement who is bound or obligated to perform a duty or payment to the obligee.

Assignee

A person or entity to whom rights or interests have been transferred by another, usually under the terms of a contract.