In Sickle-Cell Disease, as a Result of a Single Amino

question 20

Multiple Choice

In sickle-cell disease, as a result of a single amino acid change, the mutant haemoglobin tetramers associate with each other and assemble into large fibres. Based on this information alone, we can conclude that sickle-cell haemoglobin exhibits ________.

• A) only altered primary structure
• B) only altered tertiary structure
• C) only altered quaternary structure
• D) altered primary structure and altered quaternary structure; the secondary and tertiary structures may or may not be altered

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