A Defect in DNA Ligase Would Most Likely Cause

question 38

Multiple Choice

A defect in DNA ligase would most likely cause

• A) normal replication, but gaps remain in the sugar-phosphate DNA backbone.
• B) failure to remove introns from the primary mRNA.
• C) incompletely processed primary mRNA that does not get translated properly.
• D) translation to initiate normally but fail to proceed to elongation.
• E) DNA strands to separate normally but fail to join nucleotides in the growing nucleotide chain. DNA ligase is needed during DNA replication to seal breaks in the sugar-phosphate backbone after DNA polymerase joins nucleotides into a new chain. If it is defective, all other processes may occur normally, but there will be gaps remaining in the sugar-phosphate DNA backbone when DNA replication occurs.