The Reverse Transcription of HIV RNA Utilizes Host Cell TRNA

question 22

Multiple Choice

The reverse transcription of HIV RNA utilizes host cell tRNA as a primer. Specifically, a tRNA for lysine is utilized. Would a drug that blocked the host cell synthesis of the tRNA for lysine be a good drug to prevent the HIV life cycle?

• A) Yes, it should stop the reverse transcription of the HIV genome with few side effects.
• B) No, the virus would just use a different tRNA for priming.
• C) No, this would likely kill the cells that were drug treated, because they couldn't appropriately incorporate lysine into their proteins.
• D) No, the priming function of the tRNA is not essential for the HIV life cycle.

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Definitions:

Bottom-up Change

A change strategy where ideas and initiatives originate from lower-level employees and move upward through the organizational hierarchy.

Top-down Change

What occurs when change initiatives come from senior management.

Incremental Change

Gradual, step-by-step modifications or improvements made to processes, systems, or products over time, rather than dramatic or radical transformations.

Outside-in Change

An approach to change management that starts with external market or environmental sentiments and trends, then works inward to adjust organizational strategies, structures, and processes.