In a Two-Point Linkage Analysis, Genes a and B Have

question 32

Essay

In a two-point linkage analysis, genes a and b have been found to be 26 cM apart on the same chromosome.A third gene, c, has just been discovered and found to be located between a and b.A three-point linkage analysis with a, b, and c indicates that a and b are actually 33 cM apart, rather than 26 cM.Why does the three-point analysis give a different map distance for a and b than does the two-point linkage analysis, and which is more accurate?

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Definitions:

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