Mean Platelet Volume (MPV)in Humans Increases with Heart Attacks and Strokes

question 2

Multiple Choice

Mean platelet volume (MPV) in humans increases with heart attacks and strokes and is used to predict recurrence as well as mortality. MPV has high heritability. A recent GWA study found MPV to be associated with SNPs on chromosomes 12, 3, and 17, respectively. These three QTLs accounted for 4-5% of MPV variance. Which of the following is a reasonable explanation?

• A)Other loci may also account for significant variance of MPV.
• B)These SNPs must be translocated or transposed alleles.
• C)Monitoring of these SNPs should identify those at highest risk.
• D)The three SNPs, when sequenced, should show high conservation.
• E)The three SNPs will be found in genes responsible for stroke.

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