Until Recently, Only Apolipoprotein E (APOE)polymorphisms Have Been Found to Correlate

question 18

Multiple Choice

Until recently, only apolipoprotein E (APOE) polymorphisms have been found to correlate with late-onset (nonfamilial) Alzheimer disease (AD) ; however, these account for less than 50% of the V_G. New GWA studies have found a chromosome 12 risk locus. What method will likely be used by AD researchers going forward?

• A)assessment of chromosome 12 for areas of linkage disequilibrium for AD
• B)association of APOE alleles with chromosome 12 SNPs
• C)sequencing of candidate genes on chromosome 12 and search for sequence similarity
• D)genotyping of a large cohort of AD patients and matched controls using a microchip
• E)analysis of genotypes of a large number of AD patients who have none of the expected APOE alleles

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