Scientists Studying the Causes of a Type of Progressive Hearing

question 48

Multiple Choice

Scientists studying the causes of a type of progressive hearing loss known as otosclerosis want to identify the genetic contribution to the disorder. By which of the following are they most likely to find a causative gene or genes?

• A)a genome-wide association study with a large number of SNPs, using pooled DNA samples
• B)genome-wide linkage analysis studies of families whose members have otosclerosis
• C)a candidate gene case-control association study with genes known to be involved in ear development
• D)comparison of gene expression among otosclerosis patients
• E)allelic heterogeneity studies for a gene expected to be involved

---

Definitions:

Interest Rate

The percentage of a sum of money charged for its use, typically expressed as an annual percentage rate.

Convertible Debt

A type of bond or loan that can be converted into a predetermined amount of the company's equity at certain times during its life, usually at the discretion of the bondholder.

Issuing Companies

Corporations or entities that offer financial securities, like stocks or bonds, to the public in order to raise capital.

Convertible Bonds

Bonds issued by a corporation that can be converted into a predetermined number of the company's shares at certain times during their life, usually at the discretion of the bondholder.