When a Transgene Is Used in Mice to Knock Out

question 42

Multiple Choice

When a transgene is used in mice to knock out a specific function, two problems that might occur are the unintended introduction of multiple copies or abnormal gene expression. The second of these problems is related to __________.

• A)position effect
• B)homologous recombination
• C)vector insufficiency
• D)mitotic recombination
• E)unequal crossing over

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Definitions:

Myelin Sheath

The white, fatty material that forms a sheath around the axons of certain nerve cells, which are then called myelinated fibers.

Neurotransmitters

Chemicals released by neurons to transmit signals across a chemical synapse to another neuron or to an effector cell, such as a muscle or gland.

Voltage-Gated

Pertaining to ion channels that open or close in response to changes in membrane potential, playing a critical role in the conduction of electrical signals in neurons.

Neuronal Membrane

The lipid bilayer that surrounds a neuron, maintaining the cell's structure and contributing to its function by regulating the movement of ions and molecules.