How Might a Thermophilic Bacterium Use Chromosome Structure to Protect

question 2

Multiple Choice

How might a thermophilic bacterium use chromosome structure to protect against heat-induced DNA degradation?

• A)It expresses excess amounts of SMC proteins that allow the DNA to more tightly condense during periods of high heat.
• B)It can express a specialized topoisomerase that induces negative supercoiling, which provides additional chromosomal stability.
• C)It expresses a specialized topoisomerase that induces positive supercoiling, which provides additional chromosomal stability.
• D)It expresses enzymes that inhibit topoisomerase during high heat, which prevents DNA from unwinding and becoming susceptible to heat degradation.
• E)It expresses helicase, an enzyme that nicks the DNA helix and allows it to assume a more stable conformation and thus to resist heat-induced degradation.

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