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From a standpoint of natural selection, we see that the heterozygous advantage for βAβS individuals is balanced by the disadvantage to those with SCD or the wild-type alleles (and no malaria protection) . The action of these conflicting trends produces an overall increase in the mutant allele until it reaches a state where the gain and loss of βS alleles is equal. What is the term for this stable condition that allows mutant alleles to remain in a particular population?
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