Both Water and Glucose Share an -OH That Can Serve

question 12

Multiple Choice

Both water and glucose share an -OH that can serve as a substrate for a reaction with the terminal phosphate of ATP catalyzed by hexokinase. Glucose, however, is about a million times more reactive as a substrate than water. The BEST explanation is that:

• A) glucose has more -OH groups per molecule than does water.
• B) the larger glucose binds better to the enzyme; it induces a conformational change in hexokinase that brings active-site amino acids into position for catalysis.
• C) the -OH group of water is attached to an inhibitory H atom, while the glucose -OH group is attached to C.
• D) water and the second substrate, ATP, compete for the active site resulting in a competitive inhibition of the enzyme.
• E) water normally will not reach the active site because it is hydrophobic.

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