For Serine to Work Effectively as a Nucleophile in Covalent

question 70

Essay

For serine to work effectively as a nucleophile in covalent catalysis in chymotrypsin a nearby amino acid, histidine, must serve as general base catalyst. Briefly describe, in words, how these two amino acids work together.

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Definitions:

Excited Motor Activity

Refers to heightened physical activity that can be due to various neurological or psychological conditions, often characterized by restlessness or rapid movements.

Catatonic Schizophrenic

A subtype of schizophrenia characterized by severe disturbances in movement, including rigidity, posturing, and mutism.

Disorganized Schizophrenic

A subtype of schizophrenia characterized by disorganized speech, behavior, and flat or inappropriate affect.

Undifferentiated Schizophrenic

A category of schizophrenia where symptoms do not clearly fit the criteria for other subtypes, showcasing a mix of features.