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When First Synthesized, Proinsulin Has an Additional Leader or Signal

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When first synthesized, proinsulin has an additional leader or signal peptide at its amino terminus. This complete molecule is called preproinsulin and the signal peptide is cleaved off to give proinsulin. Briefly, what is the likely function of the signal peptide?


Definitions:

Unfavorable Trend

A pattern or movement in financial or operational data that suggests a negative direction, potentially indicating problems.

Trade-In Allowance

The amount a seller provides to a buyer towards the purchase of a new item by trading in an older model.

Commercial Substance

A concept in accounting indicating that a transaction significantly changes the economic situation of a business, justifying a change in the financial statements.

Accumulated Depreciation

The aggregate depreciation charges applied to a fixed asset from when it first came into operation.

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