Which Statement Is TRUE Regarding Topoisomerases During Synthesis of Nucleic

question 90

Multiple Choice

Which statement is TRUE regarding topoisomerases during synthesis of nucleic acids by E. coli RNA polymerase?

• A) DNA gyrase is required to relieve supercoils on the DNA exit side of the polymerase.
• B) Since no strand cleavage occurs, supercoiling is not a factor in the action of RNA polymerase.
• C) Positive supercoils are generated ahead of the transcription bubble.
• D) Both the DNA and the RNA product will be supercoiled.
• E) None of the statements is true.

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