Cyanide Ion (CN^-) Blocks Electron Transfer in Mitochondria at the Level

question 52

Essay

Cyanide ion (CN^-) blocks electron transfer in mitochondria at the level of cytochrome a + a₃. 2,4-Dinitrophenol (DNP) is an uncoupler of mitochondrial oxidative phosphorylation. Draw graphs (ATP synthesized vs. time and O₂ consumed vs. time) with labeled curves to show the effects of adding each of these compounds separately to a suspension of mitochondria supplied with O₂, succinate, ADP, and P_i. Use an arrow to indicate the time of drug addition.

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