The E3 Subunit of Pyruvate Dehydrogenase $\alpha$ -Ketoglutarate Dehydrogenase and the Branched-Chain

question 60

Essay

The E3 subunit of pyruvate dehydrogenase, $\alpha$ -ketoglutarate dehydrogenase and the branched-chain $\alpha$ -keto acid dehydrogenase complex is identical in each multi-enzyme complex. What reaction is catalyzed by this subunit, and why it does it make sense that it is common while E1 and E2 are not?

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Definitions:

Adaptive

Pertaining to the process of adjustment or change in behavior or physiology that enhances an organism's ability to survive and reproduce in a particular environment.

Learned Helplessness

Learned Helplessness is a condition in which an individual develops a sense of powerlessness, arising from a persistent failure to succeed or escape from a stressful situation.

Passive Behaviour

Actions characterized by submission or a lack of response to situations, often leading to the neglect of one's own needs or rights.

Aversive Events

Negative experiences or stimuli that an individual seeks to avoid or escape from, often used in conditioning and behavioral therapies.