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Which statement(s) about acetoacetate and -hydroxybutyrate is/are FALSE?
1. They can be used as a fuel by skeletal muscle.
2. They are synthesized in the liver.
3. They give rise to acetone.
4. They require acetoacetyl-CoA for their synthesis.
5. They may be regarded as water-soluble, transportable forms of citrate in the blood.
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