A 27-Year-Old Woman Arrives at the Emergency Department with Acute

question 10

Multiple Choice

A 27-year-old woman arrives at the emergency department with acute bleeding and is found to have a white count of 25.7 *10⁹L with pancytopenia: hematocrit 27%, platelet count 35*10⁹/L, and absolute neutrophil count 0.8 * 10⁹/L. She has a combination of 97% blasts and abnormal promyelocytes in her peripheral blood; some of these cells contain stacked Auer rods. What form of leukemia does she most likely have?

• A) Acute myeloid leukemia with t(15;17)(q22:q12)
• B) Chronic myeloid leukemia
• C) Acute monoblastic leukemia
• D) Acute myeloid leukemia with t(8;21)(q33:q22)

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Definitions:

Centromeres

The region of a chromosome where the two sister chromatids are joined, playing a crucial role in the movement of chromosomes during cell division.

Sister Chromatids

Identical copies formed by the replication of a chromosome, with both copies joined together by a common centromere.

Chromosomes Decondense

A process where chromosomes relax from their highly structured and compact form to a less condensed, more accessible state, typically occurring at the end of mitosis or meiosis.

Telophase

The final phase of cell division, during which the chromosomes de-condense, nuclear envelopes re-form around the divided chromosomes, completing cytokinesis.