Aldosterone, in the Figure Below, Is a Hormone Secreted by the Adrenal

question 101

Multiple Choice

Aldosterone, in the figure below, is a hormone secreted by the adrenal cortex, and insulin is a peptide secreted by the pancreas. When aldosterone contacts a target cell, it binds to an intracellular receptor and migrates to the nucleus; insulin binds to extracellular receptors on the plasma membrane. What is the MOST likely reason for this difference?

• A)Aldosterone is hydrophilic and, therefore, must enter the aqueous environment of the cytoplasm to have an effect.
• B)Aldosterone is lipid-soluble and, therefore, easily crosses the phospholipid bilayer of the plasma membrane.
• C)Aldosterone is too small to bind extracellular receptors on the plasma membrane.
• D)Insulin is too large to interact chemically with DNA.

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