The Diagram Shown Here Is Part of an RNA Transcript

question 38

Multiple Choice

The diagram shown here is part of an RNA transcript containing four open reading frames (M, H, K, and L) and three introns (1, 2, 3) . The sites labeled d1-d3 are nucleotides immediately before each intron on the 5' side and those labeled a1-a3 are nucleotides immediately after each intron on the 3' side. Splicing out an intron involves cleaving the DNA at the d and a sites at either end of the intron. A missense mutation takes place in open reading frame K. In which possible alternative splice forms of the transcript would the missense mutation not affect the polypeptide product?

• A)d1-a1 + d2-a2 + d3-a3
• B)d1-a2 + d3-a3
• C)d1-a1 + d2-a3
• D)d1-a3
• E)None of the answer options is correct.

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