SNPs Can Be Detected by Microarrays, Which Are Wafer-Like Substrates

question 20

Multiple Choice

SNPs can be detected by microarrays, which are wafer-like substrates to which millions of short stretches of DNA are attached. A microarray consists of many different squares, each one containing a different sequence of single-stranded DNA to which fluorescently labeled strands of DNAs from patients with different SNPs can hybridize. If one square will hybridize with an SNP having a C-G base pair at a particular site and an adjacent square will hybridize with an SNP having a T-A base pair at the same site, which of the following genotypes will hybridize with both squares and make them fluoresce?

• A)the homozygous C-G/C-G genotype
• B)the homozygous T-A/T-A genotype
• C)the heterozygous C-G/T-A genotype
• D)None of the answer options is correct; all of the genotypes hybridize with both squares.

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Definitions:

Inspirations

The act of drawing air into the lungs; also known as inhalation.

Expirations

The process of releasing air from the lungs through the respiratory tract, a critical phase of the breathing cycle.

Dorsal Respiratory Group

A cluster of neurons in the medulla oblongata involved in the regulation of autonomous breathing.

Pneumotaxic Center

An area of the brain located in the upper pons that regulates the pattern of breathing by inhibiting inspiration.