The following structure is a proteasome inhibitor that may find application in treating cervical cancer (J. Med. Chem. , 449) . The halides in this structure may be classified as ________ and ________. 
Definitions:
Strategic Issues
Key factors or challenges that could significantly impact an organization's ability to achieve its goals, requiring management's attention and strategic planning.
Customer Benefit
The advantage or value that a buyer gains from purchasing and using a product or service, which meets their needs or desires.
All-benefits Approach
A marketing strategy that emphasizes all the benefits of a product or service to appeal to a wide range of consumers.
Points-of-difference
Unique attributes or features that set a product, service, or brand apart from its competitors in the eyes of the target market.
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