The Following Structure Was Used in the Synthesis of a Complex

question 20

Essay

The following structure was used in the synthesis of a complex natural product shown to have cytotoxic activity (Org. Lett. 2006, 5585). Show how this structure may be constructed by a Robinson annulation by indicating the necessary starting materials.

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Definitions:

Population Transfer

The forced movement of a large group of people from one region to another, often used as a tool for political or social engineering.

Expulsion

The act of formally removing someone from an organization, institution, or country.

Genocide

The intentional and organized annihilation of a group based on their nationality, race, political beliefs, or culture.

Contact Hypothesis

The proposal that prejudiced attitudes can decline with intergroup contact.