The Following Structure Has Been Used in Monitoring the Development

question 109

Multiple Choice

The following structure has been used in monitoring the development of amyloid plaques in Alzheimer's patients (J. Med. Chem. 2011, 949) . Which sequence correctly ranks the following nitrogens in order of increasing pK_b value?

• A) 2 < 3 < 1
• B) 3 < 2 < 1
• C) 2 < 1 < 3
• D) 1 < 3 < 2

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