An Experiment Reversed Rett Symptoms by Restoring MeCP2 Expression in Young

question 35

Essay

An experiment reversed Rett symptoms by restoring MeCP2 expression in young mice. Overexpression of MeCP2 causes significant neurological defects so the investigators used an interesting technique where they inserted a transcription stop site flanked by two loxP sites in between the transcription start site and the coding region.
A. What is the advantage of this technique?
B. The investigators then used tamoxifen-inducible CreER excision of the transcription stop site. What was the function of this procedure?

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Definitions:

Organizational Development Technique

A methodology aimed at improving a company's effectiveness, health, and growth through planned interventions in the organization's processes.

Dissociation

A psychological process where a person disconnects from their thoughts, feelings, memories, or sense of identity.

Social Influence

The effect that the words, actions, or presence of other people have on an individual's thoughts, feelings, or behaviors.

Hypnotic Phenomena

Observable effects or behaviors that occur as a result of hypnosis, often involving heightened suggestibility and altered states of consciousness.