Rett Syndrome Is Caused by Mutation in an X-Linked Gene

question 26

Multiple Choice

Rett syndrome is caused by mutation in an X-linked gene called MeCP2. Why does mutation of this one gene cause so many neurological defects?

• A) CeCP2 regulates protein synthesis by global phosphorylation of protein kinases.
• B) CeCP2 causes irregular protein folding in a ubiquitous neural protein.
• C) CeCP2 binds to methylated DNA and regulates gene expression.
• D) CeCP2 is a histone that controls epigenetic regulation of gene expression.

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Definitions:

Gene-environment Correlation

This concept describes how genetic factors influence an individual's exposure to certain environments.

Epigenetics

The study of heritable changes in gene expression that do not involve changes to the underlying DNA sequence, affecting how genes are turned on or off.

Development

The process of growth and change that a person undergoes, which can be physical, cognitive, or emotional in nature.

Genetics

The branch of biology concerned with the study of genes, genetic variation, and heredity in organisms.