If α-Synuclein Knock-Out Mice and Mice with Normal α-Synuclein Were

question 6

Multiple Choice

If α-synuclein knock-out mice and mice with normal α-synuclein were injected with α-synuclein in the substantia nigra, which mice would develop symptoms of Parkinson's disease and why?

• A) The wild type mice would develop symptoms of Parkinson's as the α-synuclein would be able to cause mitochondrial dysfunction in the substantia nigra.
• B) The α-synuclein knock-out mice would develop symptoms of Parkinson's as the α-synuclein would be able to cause mitochondrial dysfunction in the substantia nigra.
• C) The α-synuclein knock-out mice would develop symptoms of Parkinson's because the α-synuclein protein would aggregate and spread cell to cell.
• D) The α-synuclein wild type mice would develop symptoms of Parkinson's because the injected α-synuclein protein would recruit native α-synuclein and the aggregates could spread cell to cell.

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