Huntington's Disease Is a Result of the Selective Loss of Striatal

question 19

Essay

Huntington's disease is a result of the selective loss of striatal neurons in the indirect pathway. One of the many symptoms of the disease is involuntary and continuous movement, called choreiform movement (chorea is derived from a Greek word for 'dance'). Based on the circuitry of the basal ganglia, why would selective loss of these neurons result in excess movement?

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