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There are three Robo genes (Robo, Robo2, and Robo3) encoding receptors for Slit, which acts as a midline repellant. In homozygous Slit mutant embryos, all axons collapse at the midline, while in homozygous Robo mutant embryos, axons re-cross the midline, resulting in thinner longitudinal tracts and thicker commissures (Figure Q7-8). Figure Q7-8
What would you expect the ventral nerve cord phenotype of a triple Robo mutant (loss of function of all three Robo genes) to be? Briefly explain your reasoning.
Leader-Member Exchange
A theory describing the dyadic relationship between leaders and their followers, focusing on the bilateral social exchange process.
Founder Syndrome
A situation in which an organization's founder maintains disproportionate power and influence, often impeding decision-making, succession planning, and organizational growth.
Organizational Change
The processes through which an organization undergoes transformation in its structure, strategies, operational methods, or culture, to adapt to changes in its environment or to improve its effectiveness.
Guiding Coalition
A group of influential individuals within an organization who work together to support and promote change initiatives and strategic directions.
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