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In the Alkylation of Cyclohexanone,better Yields Are Obtained by First

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Essay

In the alkylation of cyclohexanone,better yields are obtained by first reacting cyclohexanone with an equivalent of lithium diisopropylamide in THF and then adding the alkyl halide,rather than mixing cyclohexanone,alkyl halide,and a catalytic amount of sodium ethoxide in ethanol.Explain this observation by pointing out what the problems with the second reaction conditions might be and how the first set of reaction conditions help alleviate the problems.

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Definitions:

Asexually

Reproduction without the combination of genetic material from two different parents, resulting in offspring that are genetically identical to the parent.

Mitosis

A type of cell division in which a cell divides into two daughter cells with the same number and kind of chromosomes as the parent nucleus, typical of ordinary tissue growth.

Prophase II

A stage of meiosis where chromosomes condense, nuclear envelopes break down, and spindle apparatus forms in each of the two daughter cells from meiosis I.

Chromatin

A complex of DNA and proteins that forms chromosomes within the nucleus of eukaryotic cells, structures that condense to facilitate mitosis and meiosis.

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