Carbamazepine Has a Black Box Warning Recommending Testing for the HLA-B*1502

question 5

Multiple Choice

Carbamazepine has a Black Box warning recommending testing for the HLA-B*1502 allele in patients with Asian ancestry prior to starting therapy due to:

• A) Decreased effectiveness of carbamazepine in treating seizures in Asian patients with the HLA-B*1502 allele
• B) Increased risk for drug interactions in Asian patients with the HLA-B*1502 allele
• C) Increased risk for Stevens-Johnson syndrome in Asian patients with HLA-B*1502 allele
• D) Patients who have the HLA-B*1502 allele being more likely to have a resistance to carbamazepine

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Definitions:

Genetics And The Environment

The study of how genetic makeup and environmental factors interact to influence an individual's development and traits.

Minnesota Twin Project

A research study that examines the psychological and behavioral differences between twins, particularly focusing on the effects of genetics vs. environment.

Monozygotic Twins

Identical twins that develop from a single fertilized egg, sharing the same genetics.

Dizygotic Twins

Twins that develop from two different eggs fertilized by two different sperm, also known as fraternal twins.