Sickle Cell Anemia Evolved in Africa $\beta$ -Globin Has Reached High Frequencies Because Individuals with One Copy

question 1

Multiple Choice

Sickle cell anemia evolved in Africa.Although homozygotes of this allele have the anemia,the sickle cell allele of $\beta$ -globin has reached high frequencies because individuals with one copy of the allele have a resistance to malaria.The maintenance of both the normal and sickle cell alleles is therefore due to

• A) the Hardy-Weinberg principle.
• B) stabilizing selection.
• C) Muller's ratchet.
• D) directional selection.
• E) heterozygote advantage.

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