During a Secondary Immune Response,high-Affinity IgG Antibodies Are Produced

question 63

Multiple Choice

During a secondary immune response,high-affinity IgG antibodies are produced.Which of the following best explains why low-affinity IgM antibodies are not made?

• A)Naive pathogen-specific B cells are suppressed by negative signaling through FcγRIIB1.
• B)Naive pathogen-specific B cells isotype switch and hypermutate much more quickly during secondary immune responses.
• C)Memory B cells outnumber naive B cells.
• D)Low-affinity IgM antibodies are made only when antigen concentration is exceedingly high.

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