A Which Selectins, Mucin-Like Vascular Addressins, and Integrins Have a Role

question 9

Essay

A. Which selectins, mucin-like vascular addressins, and integrins have a role in the circulation of T cells between the blood and lymphoid tissues?
B. Describe in chronological order how T cells migrate across lymph node high endothelial venules (HEVs) from the blood by using these molecules.

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Definitions:

Asymmetric Carbon

A carbon atom bonded to four different atoms or groups, thus making it a chiral center.

R or S Configuration

A system for denoting the absolute configuration of chiral centers in molecules by their spatial arrangement.

Configurational Label

A notation used in chemistry to describe the spatial arrangement of atoms within molecules that cannot be changed without breaking chemical bonds.

Chiral Carbon

A carbon atom attached to four different groups, providing a molecule with a non-superposable mirror image.