In T Cells,allelic Exclusion of the α-Chain Locus Is Relatively

question 42

Essay

In T cells,allelic exclusion of the α-chain locus is relatively ineffective,resulting in the production of some T cells with two T-cell receptors of differing antigen specificity on their cell surface.
A.Will both these receptors have to pass positive selection for the cell to survive? Explain your answer.
B.Will both receptors have to pass negative selection for the cell to survive? Explain your answer.
C.Is there a potential problem in having T cells with dual specificity surviving these selection processes and being exported to the periphery?

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Definitions:

Machine Hours

A measure of the total time machines are operational within a specific period, often used in activity-based costing or allocation.

Factory Overhead Rate

A calculation used to allocate manufacturing overhead costs to individual units of production, based on a certain base such as labor hours or machine hours.

Machine Hours

A measure of production time, tracking the total hours that machinery is in operation during the manufacturing process.

Fabrication Department

A division within a manufacturing company where raw materials are assembled or processed to create finished goods.