MHC Class II Deficiency Is Inherited as an Autosomal Recessive

question 6

Essay

MHC class II deficiency is inherited as an autosomal recessive trait and involves a defect in the coordination of transcription factors involved in regulating the expression of all MHC class II genes (HLA-DP,HLA-DQ,and HLA-DR).
A.What is the effect of MHC class II deficiency?
B.Explain why hypogammaglobulinemia is associated with this deficiency.

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