You Are Studying an Individual with Very Low Levels of Insulin

question 77

Multiple Choice

You are studying an individual with very low levels of insulin in her blood.Further analysis indicates that cells of her pancreas are producing normal levels of this protein,but it is accumulating in the cytoplasm rather than being secreted from the cells.Which hypothesis makes the most sense to explain this observation?

• A)A small deletion has removed the nucleotides that code for the signal sequence at the amino terminus of the protein.
• B)A missense mutation has caused premature termination during translation of this protein.
• C)A chromosomal segment that includes the gene for insulin has been inverted.
• D)A two-base deletion near the middle of the gene has altered the reading frame during translation of the protein.
• E)A missense mutation has altered the ribosome-binding sequence at the 5' end of the mRNA.

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Definitions:

Net Present Value

A calculation that compares the value of a dollar today to the value of that same dollar in the future, taking inflation and returns into account to analyze the profitability of investments.

Profitability Index

A financial metric that measures the relative profitability of an investment, calculated as the present value of future cash flows divided by the initial investment cost.

Annuity

A financial product that pays out a fixed stream of payments to an individual, primarily used as an income stream for retirees.

Net Present Value

Net Present Value (NPV) is a financial metric that calculates the difference between the present value of cash inflows and outflows over a period of time, used to assess the profitability of an investment.