Use the Following Information When Answering the Corresponding Questions)

question 21

Multiple Choice

Use the following information when answering the corresponding questions) .
It has been shown that there are two distinct variants of the HIV virus Bleul et al. 1997. The HIV coreceptors CXCR4 and CCR differentially regulated on human T- lymphocytes. Proceedings of the National Academy of Science 94:1925- 30) . One virus preferentially infects macrophages and is called M- tropic. The other preferentially infects T cells and is called T- tropic. The M- tropic viruses use CCR5 and CD4 as coreceptors, and the T- tropic viruses use CXCR4 and CD4 as coreceptors. The
M- tropic viruses are found early in HIV infections; the T- tropic viruses are found late in infections, when AIDS symptoms are prevalent. T- tropic viruses are associated with a drastic decrease in T cells. Macrophages go to the site of wounds, where they are used to fight infections. T cells circulate in the body and fight infections at many sites.
-What would the result be if a drug that blocks the action of RNA polymerase was introduced into a virus- infected organism?

• A) The newly formed virions virus particles) would be unable to leave the host cell.
• B) The viral proteins would not be made, and the virus would not be able to reproduce.
• C) Viral proteins and viral DNA particles would not be able to assemble.
• D) The virus would not be able to enter new host cells.

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