APC Is a Tumor Suppressor and Acts in the Wnt

question 38

Multiple Choice

APC is a tumor suppressor and acts in the Wnt signaling pathway to prevent the TCF complex from turning on Wnt-responsive genes.Mice that lack the gene encoding TCF4 do not have the ability to maintain the pool of proliferating gut stem cells needed to renew the gut lining.What do you predict will happen in mice that lack the APC gene?

• A)Like the mice lacking TCF4, they will not be able to renew the gut lining.
• B)They will have inappropriate proliferation of gut stem cells.
• C)Mice lacking the APC gene will have a hyperactive Wnt receptor even though there is no Wnt signal.
• D)Mice lacking the APC gene will be like normal healthy mice, since APC is a tumor suppressor and thus not needed unless there is a tumor present.

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Definitions:

Gross Motor Skills

Physical abilities that involve large muscle activities such as walking, running, jumping, and climbing.

Large Muscle Groups

Collections of muscles in the body that contribute to major movements, such as those in legs, back, and chest.

Physical Play

Activities that engage the body in movement and play, promoting physical fitness, coordination, and motor skills in individuals.

Older Preschoolers

Children aged between 4 to 5 years, nearing the end of their preschool period and preparing to enter kindergarten.