People Who Inherit One Copy of the Rb (Retinoblastoma) Gene

question 53

Essay

People who inherit one copy of the Rb (retinoblastoma) gene that is normal and one copy that is mutated-that is, people who are heterozygous for Rb-have a greatly increased risk of cancer.
Given this information, do you agree or disagree with the following statement? Explain your answer.
The Rb mutation must have a dominant effect, which means that it must result in an increase in Rb function.Thus, Rb in its mutant form must be an oncogene.

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