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Both Thermogenin and 2,4-Dinitrophenol (DNP)uncouple Oxidation from ATP Synthesis

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Essay

Both thermogenin and 2,4-dinitrophenol (DNP)uncouple oxidation from ATP synthesis.Thermogenin is expressed in the mitochondria of brown fat cells in newborn animals and adult mammals that hibernate.DNP was marketed in the 1930s as a diet pill,but in addition to causing weight loss it sometimes caused death.
a.Compare the mechanisms by which these uncouplers affect ATP synthesis.
b.What function does thermogenin serve for brown fat cells?
c.Why is the rationale for DNP as a diet drug?
d.Considering locations of the effects in an animal and the possibility for allosteric regulation,suggest why thermogenin is advantageous and DNP dangerous for humans?


Definitions:

Contradiction

A situation or statement in which two or more opposing things are true or valid at the same time, highlighting a discrepancy or conflict.

Vaillant Study

A research project that tracked the physical and emotional health of a group of men over several decades, aiming to identify predictors of healthy aging.

Psychosocial Adjustment

The process of adapting to and coping with interpersonal and societal expectations and pressures.

Altruism

Behavior intended to help others out of inner concern and without expectation of external reward; may involve self-denial or self-sacrifice.

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