Allele-Specific Oligonucleotides (ASO)for the Normal and Disease Alleles of a Gene

question 5

Multiple Choice

Allele-specific oligonucleotides (ASO) for the normal and disease alleles of a gene are in one section of a microarray.The disease is a recessive trait.If a probe made from an individual's genomic DNA hybridizes with both ASOs, what can be inferred about the individual?

• A)The individual has two normal alleles.
• B)The individual has the disease.
• C)50% of the individual's children are expected to be carriers.
• D)One of the individual's parents has the disease.

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