You Are Studying a Disease That Is Known to Be

question 35

Multiple Choice

You are studying a disease that is known to be caused by a single nucleotide change in a single gene, although the effect this change ultimately has on the protein's structure and function is unknown.You have DNA samples from multiple patients that you suspect of having this disease.What is the most efficient way to test the samples for the relevant mutation?

• A)Preimplantation genetic diagnosis
• B)PCR amplification followed by Sanger DNA sequencing
• C)PCR amplification followed by gel electrophoresis
• D)High-throughput exome sequencing
• E)High-throughput genome sequencing

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Definitions:

Projective Test

A type of personality test designed to let a person respond to ambiguous stimuli, potentially revealing hidden emotions and internal conflicts.

Aptitude Test

A standardized test designed to measure an individual's potential to succeed in a certain task or to learn certain skills.

Achievement Test

An examination that measures an individual's acquired knowledge or skills in a specific area of learning, often used in educational settings.

Achievement Motivation

An individual's drive or urge to accomplish tasks and goals, typically to meet standards of excellence.