Risks for Using Retroviruses, Adenoviruses, and Lentiviruses as Vectors in Gene

question 45

Multiple Choice

Risks for using retroviruses, adenoviruses, and lentiviruses as vectors in gene therapy include all of the following except:

• A) the exogenous gene may cause disease if overexpressed or expressed in certain cell types.
• B) contaminants may be introduced during vector manufacture.
• C) antitumor responses by overexpression of cytokines may occur.
• D) there is a potential for recombination of gene therapy vectors with human endogenous sequences.

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Definitions:

Discount Rate

The interest rate used in determining the present value of future cash flows or in evaluating the attractiveness of an investment.

Project Cash Flows

The net amount of cash that is generated or expended by a particular project or investment, after accounting for all inflows and outflows.

Project Profitability Index

The ratio of the net present value of a project’s cash flows to the investment required.

Net Present Values

refers to the calculation that determines the present value of a series of future cash flows by discounting them at a certain rate, often used for assessing the profitability of investments.