In Using Somatic-Cell Hybridization Experiments, a Human Gene Was Found

question 53

Multiple Choice

In using somatic-cell hybridization experiments, a human gene was found to be located on chromosome 6. However, when lod-score analysis was done to detect linkage between this gene and a DNA marker locus also known to be on chromosome 6, no linkage could be found between the marker locus and the gene. What is the MOST likely explanation for this result?

• A) Somatic-cell hybridization experiments are not very accurate, and the gene may be on chromosome 5 or chromosome 7 instead of chromosome 6.
• B) Too few recombinants could be found to indicate linkage in the lod-score analysis.
• C) A lod-score analysis cannot be used when a DNA marker locus needs to mapped with respect to a gene locus.
• D) The gene and the DNA marker locus are so far apart on chromosome 6 that they assort independently.
• E) There were probably too few double-crossover events occurring between the two loci, so the lod score could not be determined accurately.

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Definitions:

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